December 18, 2025

NFL Week 16 (‘25) Best Odds Compared (Sportsbook)

Week 16 NFL Odds - Novig vs DraftKings

Week 16 has arrived. Below is a full look at this week’s NFL odds across spreads, totals, and moneylines, along with spots where Novig is beating sportsbooks like DraftKings so you can see how better pricing can make a real difference over time.

If you want the strongest possible number on every NFL side and total, the platform you use matters just as much as the pick itself. Instead of paying the built in sportsbook margin, Novig lets you ditch the vig and trade at sharper prices. 

Here are the NFL odds for all Week 16 matchups.

NFL Spreads Week 16

The largest spread on the Week 16 slate appears in one game. Raiders vs Texans is set at 14.5 points, making Houston the biggest favorite of the week. Bills vs Browns follows closely behind with Buffalo favored by 10.5 points.

The smallest spread of the week is 1.5 points and seen in the Rams vs Seahawks, Chargers vs Cowboys, and Packers vs Bears matchups.

NFL Totals Week 16

The Steelers vs Lions matchup is projected to be the highest scoring game of Week 16, with the total set at 51.5 points. 

The lowest over under on the Week 16 slate belongs to the Raiders vs Texans matchup, with the total set at 37.5 points. Chiefs vs Titans also sits near the bottom, pointing to a more defense focused game script.

NFL Moneylines Week 16

The largest moneyline favorites this week are the Texans, Bills, and Eagles. All three teams enter their matchups as heavy favorites and carry very substantial negative moneylines.

NFL Lines and Line Shopping Week 16

Odds are provided from DraftKings Sportsbook and Novig Prediction Market and updated as of Thursday, Dec. 18th at 11:00 a.m. ET.

This overview compares Week 16 lines and odds across FanDuel and Novig to highlight where the best prices can be found.

Thursday, Dec 18th

  1. LA Rams vs SEA Seahawks

Seattle Seahawks are a slight favorite in their Week 16 matchup against the Los Angeles Rams. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Los Angeles Rams @ Seattle Seahawks
FanDuel
Novig Best price
Spread
LA +1.5(-110)
SEA -1.5(-110)
LA +1.5(-106)
SEA -1.5(+102)
Total
LA Over 42.5(-115)
SEA Under 42.5(-105)
LA Over 43.5(+107)
SEA Under 43.5(-114)
Moneyline
LA(+106)
SEA(-124)
LA(+111)
SEA(-112)

Saturday, Dec 20th

  1. PHI Eagles vs WAS Commanders

Philadelphia Eagles are a solid favorite in their Week 16 matchup against the Washington Commanders. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Philadelphia Eagles @ Washington Commanders
FanDuel
Novig Best price
Spread
PHI -6.5(-110)
WAS +6.5(-110)
PHI -6.5(-105)
WAS +6.5(+102)
Total
PHI Over 44.5(-105)
WAS Under 44.5(-115)
PHI Over 44.5(+105)
WAS Under 44.5(-109)
Moneyline
PHI(-300)
WAS(+245)
PHI(-276)
WAS(+275)
  1. GB Packers vs CHI Bears

Green Bay Packers are a slight favorite in their Week 16 matchup against the Chicago Bears. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Green Bay Packers @ Chicago Bears
FanDuel
Novig Best price
Spread
GB -1.5(-102)
CHI +1.5(-120)
GB -1.5(+113)
CHI +1.5(-120)
Total
GB Over 46.5(-112)
CHI Under 46.5(-108)
GB Over 46.5(-111)
CHI Under 46.5(-101)
Moneyline
GB(-112)
CHI(-104)
GB(-101)
CHI(-103)

Sunday, Dec 21st

  1. TB Buccaneers vs CAR Panthers

Tampa Bay Buccaneers are a slight favorite in their Week 16 matchup against the Carolina Panthers. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Tampa Bay Buccaneers @ Carolina Panthers
FanDuel
Novig Best price
Spread
TB -3(-110)
CAR +3(-110)
TB -2.5(-119)
CAR +2.5(+111)
Total
TB Over 45.5(-110)
CAR Under 45.5(-110)
TB Over 45.5(-102)
CAR Under 45.5(-105)
Moneyline
TB(-158)
CAR(+134)
TB(-148)
CAR(+144)
  1. BUF Bills vs CLE Browns

Buffalo Bills are a heavy favorite in their Week 16 matchup against the Cleveland Browns. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Buffalo Bills @ Cleveland Browns
FanDuel
Novig Best price
Spread
BUF -10.5(-105)
CLE +10.5(-115)
BUF -10.5(-102)
CLE +10.5(-106)
Total
BUF Over 41.5(-110)
CLE Under 41.5(-110)
BUF Over 41.5(-102)
CLE Under 41.5(-109)
Moneyline
BUF(-650)
CLE(+480)
BUF(-525)
CLE(+495)
  1. LA Chargers vs DAL Cowboys

Dallas Cowboys are a slight favorite in their Week 16 matchup against the Los Angeles Chargers. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Los Angeles Chargers @ Dallas Cowboys
FanDuel
Novig Best price
Spread
LAC +2.5(-112)
DAL -2.5(-108)
LAC +1.5(+102)
DAL -1.5(-110)
Total
LAC Over 49.5(-115)
DAL Under 49.5(-105)
LAC Over 49.5(-105)
DAL Under 49.5(-108)
Moneyline
LAC(+108)
DAL(-126)
LAC(+122)
DAL(-126)
  1. NY Jets vs NO Saints

New Orleans Saints are a solid favorite in their Week 16 matchup against the New York Jets. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

New York Jets @ New Orleans Saints
FanDuel
Novig Best price
Spread
NYG +4.5(-105)
NO -4.5(-115)
NYG +4.5(+112)
NO -4.5(-115)
Total
NYG Over 40.5(-105)
NO Under 40.5(-115)
NYG Over 40.5(+101)
NO Under 40.5(-108)
Moneyline
NYG(+194)
NO(-235)
NYG(+213)
NO(-224)
  1. MIN Vikings vs NY Giants

Minnesota Vikings are a slight favorite in their Week 16 matchup against the New York Giants. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Minnesota Vikings @ New York Giants
Novig
Novig Best price
Spread
MIN -2.5(-122)
NYJ +2.5(+100)
MIN -2.5(-114)
NYJ +2.5(+111)
Total
MIN Over 43.5(-115)
NYJ Under 43.5(-105)
MIN Over 43.5(+105)
NYJ Under 43.5(-107)
Moneyline
MIN(-154)
NYJ(+130)
MIN(-142)
NYJ(+138)
  1. KC Chiefs vs TEN Titans

Kansas City Chiefs are a solid favorite in their Week 16 matchup against the Tennessee Titans. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Kansas City Chiefs @ Tennessee Titans
FanDuel
Novig Best price
Spread
KC -3(-110)
TEN +3(-110)
KC -3.5(+121)
TEN +3.5(-125)
Total
KC Over 37.5(-102)
TEN Under 37.5(-120)
KC Over 37.5(-106)
TEN Under 37.5(-106)
Moneyline
KC(-168)
TEN(+142)
KC(-156)
TEN(+151)
  1. CIN Bengals vs MIA Dolphins

Cincinnati Bengals are a solid favorite in their Week 16 matchup against the Miami Dolphins. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Cincinnati Bengals @ Miami Dolphins
FanDuel
Novig Best price
Spread
CIN -4.5(-110)
MIA +4.5(-110)
CIN -4.5(+102)
MIA +4.5(-109)
Total
CIN Over 47.5(-108)
MIA Under 47.5(-112)
CIN Over 47.5(-109)
MIA Under 47.5(+100)
Moneyline
CIN(-220)
MIA(+184)
CIN(-199)
MIA(+193)
  1. ATL Falcons vs ARI Cardinals

Atlanta Falcons are a slight favorite in their Week 16 matchup against the Arizona Cardinals. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Atlanta Falcons @ Arizona Cardinals
FanDuel
Novig Best price
Spread
ATL -2.5(-115)
ARI +2.5(-105)
ATL -2.5(-119)
ARI +2.5(+115)
Total
ATL Over 47.5(-115)
ARI Under 47.5(-105)
ATL Over 48.5(-102)
ARI Under 48.5(-113)
Moneyline
ATL(-148)
ARI(+126)
ATL(-138)
ARI(+137)
  1. JAX Jaguars vs DEN Broncos

Denver Broncos are a slight favorite in their Week 16 matchup against the Jacksonville Jaguars. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Jacksonville Jaguars @ Denver Broncos
FanDuel
Novig Best price
Spread
JAX +3(-105)
DEN -3(-115)
JAX +3.5(-122)
DEN -3.5(+115)
Total
JAX Over 46.5(-110)
DEN Under 46.5(-110)
JAX Over 46.5(-111)
DEN Under 46.5(-103)
Moneyline
JAX(+144)
DEN(-172)
JAX(+156)
DEN(-161)
  1. PIT Steelers vs DET Lions

Detroit Lions are a solid favorite in their Week 16 matchup against the Pittsburgh Steelers. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Pittsburgh Steelers @ Detroit Lions
FanDuel
Novig Best price
Spread
PIT +6.5(-102)
DET -6.5(-120)
PIT +6.5(+108)
DET -6.5(-111)
Total
PIT Over 51.5(-110)
DET Under 51.5(-110)
PIT Over 52.5(+106)
DET Under 52.5(-113)
Moneyline
PIT(+265)
DET(-330)
PIT(+282)
DET(-300)
  1. LV Raiders vs HOU Texans

Houston Texans are a heavy favorite in their Week 16 matchup against the Las Vegas Raiders. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

Las Vegas Raiders @ Houston Texans
FanDuel
Novig Best price
Spread
LV +14.5(-118)
HOU -14.5(-104)
LV +13.5(+100)
HOU -13.5(-111)
Total
LV Over 37.5(-115)
HOU Under 37.5(-105)
LV Over 38.5(-101)
HOU Under 38.5(-114)
Moneyline
LV(+750)
HOU(-1200)
LV(+826)
HOU(-900)
  1. NE Patriots vs BAL Ravens

Baltimore Ravens are a slight favorite in their Week 16 matchup against the New England Patriots. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

New England Patriots @ Baltimore Ravens
FanDuel
Novig Best price
Spread
NE +2.5(+100)
BAL -2.5(-122)
NE +2.5(+117)
BAL -2.5(-125)
Total
NE Over 47.5(-115)
BAL Under 47.5(-105)
NE Over 48.5(-106)
BAL Under 48.5(-106)
Moneyline
NE(+130)
BAL(-154)
NE(+142)
BAL(-144)

Monday, Dec 22nd

  1. SF 49ers vs IND Colts

San Francisco 49ers are a heavy favorite in their Week 16 matchup against the Indianapolis Colts. Price is much more favorable on the Novig (right) platform compared to FanDuel (left). 

San Francisco 49ers @ Indianapolis Colts
FanDuel
Novig Best price
Spread
SF -5.5(-115)
IND +5.5(-105)
SF -5.5(-111)
IND +5.5(+107)
Total
SF Over 46.5(-115)
IND Under 46.5(-105)
SF Over 46.5(-102)
IND Under 46.5(-108)
Moneyline
SF(-270)
IND(+220)
SF(-248)
IND(+241)

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